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Publication datasheet
Title:
Synthesis and biological evaluation of gallic acid analogs.
Authors:
Barontini, M.; Proietti Silvestri, I.; Nardi, V.; Crisante, F.; Pepe, G.; Pari, L.; Gallucci, F.; Bovicelli, P.; Righi, G.
Year:
2013
Languages:
ENG, eng
Journal:
Medicinal Chemistry Research
Kind of publication:
Cartaceo
Location:
New York
Editor:
Springer
Abstract in Italian:
Abstract in English:
A novel and efficient synthesis of pyrogallol moiety through a copper(I)-mediated CO bond forming reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative are reported. Particular attention to dimethyl carbonate as an eco-friendly solvent/reactant has been paid, in order to improve the eco-compatibility of the whole synthetic pathway. Furthermore, the genotoxicity, cytotoxicity and the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative have been investigated.
Link:
http://dx.doi.org/10.1007/s00044-012-0052-8

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