Synthesis and biological evaluation of gallic acid analogs.
Barontini, M.; Proietti Silvestri, I.; Nardi, V.; Crisante, F.; Pepe, G.; Pari, L.; Gallucci, F.; Bovicelli, P.; Righi, G.
Medicinal Chemistry Research
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|Abstract in Italian:|
|Abstract in English:|
A novel and efficient synthesis of pyrogallol
moiety through a copper(I)-mediated C–O bond forming
reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl
alcohol and its methyl derivative are
reported. Particular attention to dimethyl carbonate as an
eco-friendly solvent/reactant has been paid, in order to
improve the eco-compatibility of the whole synthetic
pathway. Furthermore, the genotoxicity, cytotoxicity and
the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol
and its methyl derivative have been investigated.